Actor Eric Dane, widely known for his roles in Grey’s Anatomy and Euphoria, has passed away at the age of 53 after living with amyotrophic lateral sclerosis (ALS).
The California native, famous for portraying Dr. Mark Sloan — affectionately called “Dr. McSteamy” — on Grey’s Anatomy, and Cal Jacobs on Euphoria, publicly shared his ALS diagnosis last year. ALS, the most common form of motor neurone disease, is a progressive condition that affects nerve cells in the brain and spinal cord. In the months before his death, he had been actively raising awareness about the illness.
His family confirmed that he died on Thursday afternoon following a brave fight with the disease. He was surrounded by his wife, actress Rebecca Gayheart, and their daughters, Billie and Georgia. In their statement, the family described his children as the center of his life and expressed gratitude for the outpouring of love and support from fans.
Dane rose to prominence on Grey’s Anatomy, quickly becoming a fan favorite for his charm and screen presence. He later showcased his range by taking on more complex roles, including Cal Jacobs in Euphoria. Over the years, he also appeared in television series such as Charmed and The Last Ship, and featured in films including Marley & Me, Valentine’s Day, and Burlesque.
In an interview last summer, he spoke candidly about the emotional toll of his diagnosis, admitting he struggled with anger and fears about leaving his daughters too soon, especially after losing his own father at a young age.
Following news of his passing, tributes poured in from colleagues and friends. Co-stars remembered his humor, warmth, and talent, while collaborators described working with him as both an honor and a privilege.
Eric Dane leaves behind a lasting legacy in television and film, with a career spanning more than 30 years.


